Clonal selection and drift drive both normal tissue and cancer development. However, the
biological mechanisms and environmental conditions underpinning these processes remain …

The intestinal epithelium is crucial to maintaining a healthy gut. Central to this are the crypts
of Lieberkühn, which coordinate the rapid self-renewal of the epithelium to protect the small …

The rise of longitudinal single-cell sequencing experiments on patient-derived cell cultures,
xenografts and organoids is opening new opportunities to track cancer evolution, assess the …

One of the key challenges in current cancer research is the development of computational
strategies to support clinicians in the identification of successful personalized treatments …

Background The combined effects of biological variability and measurement-related errors
on cancer sequencing data remain largely unexplored. However, the spatio-temporal …

Three-dimensional (3D) computational tissue models can provide a comprehensive
description of tissue dynamics at the molecular, cellular and tissue level. Moreover, they can …

Background Dynamical models of gene regulatory networks (GRNs) are highly effective in
describing complex biological phenomena and processes, such as cell differentiation and …

Colorectal cancer (CRC) is one of the major causes of death in the developed world and
forms a canonical example of tumorigenesis. CRC arises from a string of mutations of …

In the first part of this invited paper we review the role of both extrinsic and intrinsic
stochasticity in sha** the dynamics of biomolecular networks. In particular, we stress the …

We introduce a Chaste plugin for the generation and the simulation of Gene Regulatory
Networks (GRNs) in multiscale models of multicellular systems. Chaste is a widely used and …