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HMGB1 in health and disease
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
High-mobility group box 1 (HMGB1) and autophagy in acute lung injury (ALI): a review
L Qu, C Chen, YY Chen, Y Li, F Tang… - … medical journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Acute lung injury (ALI) is a life-threatening clinical syndrome in critically ill patients. The
identification of novel biological markers for the early diagnosis of ALI and the development …
identification of novel biological markers for the early diagnosis of ALI and the development …
[HTML][HTML] Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy
K Dokladny, MN Zuhl, M Mandell… - Journal of Biological …, 2013 - Elsevier
The eukaryotic cell depends on multitiered homeostatic systems ensuring maintenance of
proteostasis, organellar integrity, function and turnover, and overall cellular viability. At the …
proteostasis, organellar integrity, function and turnover, and overall cellular viability. At the …
A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis
Background Sepsis is a life-threatening condition caused by a dysregulated host response
to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological …
to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological …
Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression
MN Zuhl, KR Lanphere, L Kravitz… - Journal of applied …, 2014 - journals.physiology.org
The objectives of this study are threefold: 1) to assess whether 7 days of oral glutamine
(GLN) supplementation reduces exercise-induced intestinal permeability; 2) whether …
(GLN) supplementation reduces exercise-induced intestinal permeability; 2) whether …
Host cell glutamine metabolism as a potential antiviral target
A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome
and capsid together are known as the nucleocapsid, which has an envelope containing a …
and capsid together are known as the nucleocapsid, which has an envelope containing a …
Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway
Objectives: To examine whether niacin attenuates lung inflammation and improves survival
during sepsis and to determine whether the beneficial effects of niacin are associated with …
during sepsis and to determine whether the beneficial effects of niacin are associated with …
Glutamine administration ameliorates sepsis-induced kidney injury by downregulating the high-mobility group box protein-1-mediated pathway in mice
Acute kidney injury (AKI) is a severe complication of sepsis. High-mobility group box
(HMGB)-1 was implicated as a late mediator of lethal systemic inflammation in sepsis. Since …
(HMGB)-1 was implicated as a late mediator of lethal systemic inflammation in sepsis. Since …
Role of apoptosis in amplifying inflammatory responses in lung diseases
EP Schmidt, RM Tuder - Journal of cell death, 2010 - journals.sagepub.com
Apoptosis is an important contributor to the pathophysiology of lung diseases such as acute
lung injury (ALI) and chronic obstructive pulmonary disease (COPD). Furthermore, the …
lung injury (ALI) and chronic obstructive pulmonary disease (COPD). Furthermore, the …
Emerging therapies for smoke inhalation injury: a review
Background Smoke inhalation injury increases overall burn mortality by up to 20 times.
Current therapy remains supportive with a failure to identify an optimal or targeted treatment …
Current therapy remains supportive with a failure to identify an optimal or targeted treatment …