Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Plasma xanthine oxidase (XO) activity was defined as a source of enhanced vascular
superoxide (O) and hydrogen peroxide (H2O2) production in both sickle cell disease (SCD) …

Journal of Hypertension Log in or Register Subscribe to journalSubscribe Get new issue
alertsGet alerts Submit your manuscript Secondary Logo Journal Logo Advanced Search …

Accumulating evidence supports the importance of redox signaling in the pathogenesis and
progression of hypertension. Redox signaling is implicated in many different physiological …

Background Child blood pressure (BP) is predictive of future cardiovascular risk. Prenatal
exposure to metals has been associated with higher BP in childhood, but most studies have …

Increased production of oxygen free radicals may play a role in many diseases such as
hypertension. As evidence indicates that xanthine oxidase may be involved in creating these …

A change in endothelial function is a common phenomenon in patients with essential
hypertension and in animals with hypertension, whether primary or induced by a salt-rich …

Objective: To determine if oxygen free radicals derived from xanthine oxidase are involved
in the development of salt-induced hypertension. Enhanced production of oxygen free …

Xanthine oxidoreductase (XOR) inhibitor administration reduces uric acid and reactive
oxygen species (ROS) production, and also lowers blood pressure (BP). However, the …