The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …

Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

The notion of “engagement,” which plays an important role in various domains of
psychology, is gaining increased currency as a concept that is critical to the success of …

A group of European experts was commissioned by the European Chapter of the
International Federation of Clinical Neurophysiology to gather knowledge about the state of …

Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Within the last two decades, many studies have addressed the clinical phenomenon of
Internet-use disorders, with a particular focus on Internet-gaming disorder. Based on …

The impaired response inhibition and salience attribution (iRISA) model proposes that
impaired response inhibition and salience attribution underlie drug seeking and taking. To …

Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …