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Mechanisms of cell death in oxidative stress
SW Ryter, HP Kim, A Hoetzel, JW Park… - Antioxidants & redox …, 2007 - liebertpub.com
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …
environmental stress have long been implicated in tissue injury in the context of a variety of …
Pathophysiology of polytrauma
Immediate and early trauma deaths are determined by primary brain injuries, or significant
blood loss (haemorrhagic shock), while late mortality is caused by secondary brain injuries …
blood loss (haemorrhagic shock), while late mortality is caused by secondary brain injuries …
Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition
Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic
inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been …
inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been …
The microcirculation is the motor of sepsis
C Ince - Critical care, 2005 - Springer
Regional tissue distress caused by microcirculatory dysfunction and mitochondrial
depression underlies the condition in sepsis and shock where, despite correction of …
depression underlies the condition in sepsis and shock where, despite correction of …
Neutrophils in development of multiple organ failure in sepsis
Multiple organ failure is a major threat to the survival of patients with sepsis and systemic
inflammation. In the UK and in the USA, mortality rates are currently comparable with and …
inflammation. In the UK and in the USA, mortality rates are currently comparable with and …
Compensatory anti-inflammatory response syndrome
The concept of 'Compensatory anti-inflammatory response syndrome'(CARS) was proposed
in 1997 by Roger Bone (1941–1997) to qualify the consequences of the counter-regulatory …
in 1997 by Roger Bone (1941–1997) to qualify the consequences of the counter-regulatory …
Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI
Background Sepsis is a life-threatening condition accompanied by organ dysfunction
subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis …
subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis …
Marked alterations of neutrophil functions during sepsis-induced immunosuppression
J Demaret, F Venet, A Friggeri… - Journal of Leucocyte …, 2015 - academic.oup.com
Severe septic syndromes deeply impair innate and adaptive immunity and are responsible
for sepsis-induced immunosuppression. Although neutrophils represent the first line of …
for sepsis-induced immunosuppression. Although neutrophils represent the first line of …
Apoptosis: A review of pro‐apoptotic and anti‐apoptotic pathways and dysregulation in disease
MA O'Brien, R Kirby - … of veterinary emergency and critical care, 2008 - Wiley Online Library
Objective–To review the human and veterinary literature on the biology of apoptosis in
health and disease. Data Sources–Data were examined from the human and veterinary …
health and disease. Data Sources–Data were examined from the human and veterinary …
Bacterial sensing, cell signaling, and modulation of the immune response during sepsis
Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …
proposed, a large amount of new information has been generated showing a much more …