Recent progress in broadly neutralizing antibodies to HIV
D Sok, DR Burton - Nature immunology, 2018 - nature.com
In this Review, we highlight some recent developments in the discovery and application of
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide
S Wang, F Matassoli, B Zhang, T Liu, CH Shen… - Cell reports, 2023 - cell.com
Elicitation of antibodies that neutralize the tier-2 neutralization-resistant isolates that typify
HIV-1 transmission has been a long-sought goal. Success with prefusion-stabilized …
HIV-1 transmission has been a long-sought goal. Success with prefusion-stabilized …
Antibody lineages with vaccine-induced antigen-binding hotspots develop broad HIV neutralization
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …
Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability
J Gorman, CSF Cheung, Z Duan, L Ou, M Wang… - Nature …, 2024 - nature.com
Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …
HIV-1 envelope and MPER antibody structures in lipid assemblies
Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane
protein have long been complicated by challenges associated with inherent flexibility of the …
protein have long been complicated by challenges associated with inherent flexibility of the …
Longitudinal analysis reveals early development of three MPER-directed neutralizing antibody lineages from an HIV-1-infected individual
SJ Krebs, YD Kwon, CA Schramm, WH Law… - Immunity, 2019 - cell.com
Lineage-based vaccine design is an attractive approach for eliciting broadly neutralizing
antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have …
antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have …
Structure of super-potent antibody CAP256-VRC26. 25 in complex with HIV-1 envelope reveals a combined mode of trimer-apex recognition
Antibodies targeting the V1V2 apex of the HIV-1 envelope (Env) trimer comprise one of the
most commonly elicited categories of broadly neutralizing antibodies. Structures of these …
most commonly elicited categories of broadly neutralizing antibodies. Structures of these …
Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation
Summary Soluble HIV-1 envelope (Env) trimers may serve as effective vaccine
immunogens. The widely utilized SOSIP trimers have been paramount for structural studies …
immunogens. The widely utilized SOSIP trimers have been paramount for structural studies …
[HTML][HTML] Sera antibody repertoire analyses reveal mechanisms of broad and pandemic strain neutralizing responses after human norovirus vaccination
Rapidly evolving RNA viruses, such as the GII. 4 strain of human norovirus (HuNoV), and
their vaccines elicit complex serological responses associated with previous exposure …
their vaccines elicit complex serological responses associated with previous exposure …