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Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - pmc.ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
Pathomic fusion: an integrated framework for fusing histopathology and genomic features for cancer diagnosis and prognosis
Cancer diagnosis, prognosis, mymargin and therapeutic response predictions are based on
morphological information from histology slides and molecular profiles from genomic data …
morphological information from histology slides and molecular profiles from genomic data …
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
BD Choi, X Yu, AP Castano, AA Bouffard… - Nature …, 2019 - nature.com
Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …
Updated insights on EGFR signaling pathways in glioma
A Oprita, SC Baloi, GA Staicu, O Alexandru… - International journal of …, 2021 - mdpi.com
Nowadays, due to recent advances in molecular biology, the pathogenesis of glioblastoma
is better understood. For the newly diagnosed, the current standard of care is represented by …
is better understood. For the newly diagnosed, the current standard of care is represented by …
[HTML][HTML] Molecular biomarkers in glioblastoma: a systematic review and meta-analysis
Background: Glioblastoma (GBM) is a highly aggressive cancer with poor prognosis that
needs better treatment modalities. Moreover, there is a lack of reliable biomarkers to predict …
needs better treatment modalities. Moreover, there is a lack of reliable biomarkers to predict …
A critical overview of targeted therapies for glioblastoma
KK Jain - Frontiers in oncology, 2018 - frontiersin.org
Over the past century, treatment of malignant tumors of the brain has remained a challenge.
Refinements in neurosurgical techniques, discovery of powerful chemotherapeutic agents …
Refinements in neurosurgical techniques, discovery of powerful chemotherapeutic agents …
Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
U Fatima, S Roy, S Ahmad, S Ali, WM Elkady… - Frontiers in …, 2022 - frontiersin.org
Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in
combination with other herbs, as a memory and learning enhancer, sedative, and anti …
combination with other herbs, as a memory and learning enhancer, sedative, and anti …
Recent advances in the therapeutic strategies of glioblastoma multiforme
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …