Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Biocatalytic oxidation reactions: a chemist's perspective

JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

W Finnigan, LJ Hepworth, SL Flitsch, NJ Turner - Nature catalysis, 2021 - nature.com
As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Alcohol dehydrogenases as catalysts in organic synthesis

AS de Miranda, CDF Milagre, F Hollmann - Frontiers in Catalysis, 2022 - frontiersin.org
Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective
oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this …

Predicting enzymatic reactions with a molecular transformer

D Kreutter, P Schwaller, JL Reymond - Chemical science, 2021 - pubs.rsc.org
The use of enzymes for organic synthesis allows for simplified, more economical and
selective synthetic routes not accessible to conventional reagents. However, predicting …

Whole‐cell cascade biotransformations for one‐pot multistep organic synthesis

S Wu, Z Li - ChemCatChem, 2018 - Wiley Online Library
Performing one‐pot multi‐catalysis reactions is a revolutionary tool for multistep synthesis,
representing a fast‐develo** theme in catalysis field. To develop cascade reactions …

Baeyer-Villiger oxidations: biotechnological approach

M Bučko, P Gemeiner, A Schenkmayerová… - Applied microbiology …, 2016 - Springer
Abstract Baeyer-Villiger monooxygenases (BVMOs) are a very well-known and intensively
studied class of flavin-dependent enzymes. Their substrate promiscuity, high chemo-, regio …

Photobiocatalytic Oxyfunctionalization with High Reaction Rate using a Baeyer–Villiger Monooxygenase from Burkholderia xenovorans in Metabolically Engineered …

E Erdem, L Malihan-Yap, L Assil-Companioni… - ACS …, 2021 - ACS Publications
Baeyer–Villiger monooxygenases (BVMOs) catalyze the oxidation of ketones to lactones
under very mild reaction conditions. This enzymatic route is hindered by the requirement of a …

Recent advances in enzymatic oxidation of alcohols

J Liu, S Wu, Z Li - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Discovery of new Cu 2+ radical oxidases with high activity and broad substrate
range.•Development of computational tool for engineering cofactor preference of alcohol …