Neuroprotection is a proactive approach to safeguarding the nervous system, including the
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …

Friedreich ataxia is the most common of the hereditary ataxias. It is due to homozygous/
compound heterozygous mutations in FXN. This gene encodes frataxin, a protein largely …

Objective Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia
tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP …

One hundred and fifty years since Nikolaus Friedreich's first description of the degenerative
ataxic syndrome which bears his name, his description remains at the core of the classical …

The cerebellum is involved in multiple closed-loops circuitry which connect the cerebellar
modules with the motor cortex, prefrontal, temporal, and parietal cortical areas, and …

Friedreich's ataxia (FRDA) is a devastating, multisystemic disorder caused by recessive
mutations in the mitochondrial protein frataxin (FXN). FXN participates in the biosynthesis of …

Objective Friedreich ataxia (FRDA) is a progressive neurodegenerative disorder of adults
and children. This study analyzed neurological outcomes and changes to identify predictors …

Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disease
(NDD) characterized primarily by progressive sensory and spinocerebellar ataxia …

The interest in the role of ferrous iron in diabetes pathophysiology has been revived by
recent evidence of iron as an important determinant of pancreatic islet inflammation and as a …

Background Neuroinflammation is proposed to accompany, or even contribute to,
neuropathology in Friedreich ataxia (FRDA), with implications for disease treatment and …