Ru (II) compounds: next-generation anticancer metallotherapeutics?

S Thota, DA Rodrigues, DC Crans… - Journal of medicinal …, 2018 - ACS Publications
Metal based therapeutics are a precious class of drugs in oncology research that include
examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and …

Ruthenium complexes: an emerging ground to the development of metallopharmaceuticals for cancer therapy

M Abid, F Shamsi, A Azam - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
GLOBOCAN 2012 estimates 14.1 million new cancer cases and 8.2 million cancer-related
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …

Half-sandwich arene ruthenium (II) and osmium (II) thiosemicarbazone complexes: solution behavior and antiproliferative activity

A Gatti, A Habtemariam, I Romero-Canelón… - …, 2018 - ACS Publications
We report the synthesis, characterization, and antiproliferative activity of organo-osmium (II)
and organo-ruthenium (II) half-sandwich complexes [(η6-p-cym) Os (L) Cl] Cl (1 and 2) and …

Synthesis, DNA binding, and antiproliferative activity of novel acridine-thiosemicarbazone derivatives

SMV Almeida, EA Lafayette… - International journal of …, 2015 - mdpi.com
In this work, the acridine nucleus was used as a lead-compound for structural modification
by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9 …

Synthesis, characterization, DNA binding and anticancer activities of the imidazolidine-functionalized (NHC) Ru (II) complexes

C Gürses, A Aktaş, S Balcıoğlu, A Fadhilah… - Journal of Molecular …, 2022 - Elsevier
Here, we present a study on the synthesis and biological properties of the ruthenium
complexes having naphthyl substituted NHC ligands, which are of great importance for drug …

[HTML][HTML] Synthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru (II) complexes

S Thota, S Vallala, R Yerra, DA Rodrigues… - International journal of …, 2016 - Elsevier
We report on the synthesis of novel Ru (II) compounds (Ru-1 to Ru-8) bearing R-pdc, 4-Cl-
pbinh ligands (where R= 4-CF 3, 4-F, 4-OH pdc= 3-phenyl-5-(1H-pyrrol-2-yl)-4, 5-dihydro …

Synthesis and characterization of thiosemicarbazone-functionalized organoruthenium (II)-arene complexes: Investigation of antitumor characteristics in colorectal …

E Subasi, EB Atalay, D Erdogan, B Sen… - Materials Science and …, 2020 - Elsevier
In the current study, organoruthenium (II)-arene complexes (I-IV) have been prepared by the
reaction of [{(η 6-p-cym) RuCl} 2 (μ-Cl) 2] with new thiosemicarbazones (TSC1–4). The …

Cytotoxicity evaluation and DNA interaction of Ru II-bipy complexes containing coumarin-based ligands

PSVB de Almeida, HJ de Arruda, GLS Sousa… - Dalton …, 2021 - pubs.rsc.org
Although there are various treatment options for cancer, this disease still has caused an
increasing number of deaths, demanding more efficient, selective and less harmful drugs …

Development of arene ruthenium antitumor complexes

W Su, Z Tang, P Li - Mini reviews in medicinal chemistry, 2016 - benthamdirect.com
The organometallic arene ruthenium complexes are rapidly advancing. In particular, the
organoruthenium complexes of the type [(η6-arene) Ru (X)(Y)(Z)] have attracted increasing …

Ruthenium (ii) polypyridyl complexes with visible light-enhanced anticancer activity and multimodal cell imaging

Y Kang, Y Zhao, Y Wei, Y Zhang, Z Wang, Q Luo… - Dalton …, 2023 - pubs.rsc.org
Ruthenium (II) polypyridyl complexes have drawn growing attention due to their
photophysical properties and anticancer activity. Herein we report four ruthenium (II) …