The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …

In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …

Although prostate cancer is known to have a strong genetic basis and is influenced by both
common and rare variants, the ability to investigate the combined effect of such genetic risk …

Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an
inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) …

Cortical morphology is a key determinant of cognitive ability and mental health. Its
development is a highly intricate process spanning decades, involving the coordinated …

Inflammatory bowel disease (IBD), with Crohn's disease and ulcerative colitis as main
subtypes, is a prototypical multifactorial disease with both genetic and environmental factors …

Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for
bone mineral density have demonstrated potential clinical utility. However, the value of rare …

Despite thousands of common genetic loci of major depression disorders (MDD) have been
identified by GWAS to date, a large proportion of genetic variation predisposing to MDD …

Polygenic risk score (PRS) and rare monogenic variant screening are valuable tools for
predicting cancer risk and identifying individuals at high risk. Integrating both common and …