Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Biological ion channels are nanoscale transmembrane pores. When water and ions are
enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit …

Water is of the utmost importance for life and technology. However, a genuinely predictive
ab initio model of water has eluded scientists. We demonstrate that a fully ab initio approach …

Abstract A primary calcium (Ca 2+) entry pathway into non-excitable cells is through the
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …

Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …

Store-operated calcium entry (SOCE) generates sustained and oscillatory cytosolic Ca2+
signals that regulate diverse cellular functions such as transcription, differentiation, motility …

Abstract Store-operated Ca2+ release-activated Ca2+ (CRAC) channels constitute a major
pathway for Ca2+ influx and mediate many essential signalling functions in animal cells, yet …

Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable
cells and is required for proper immune function. While the channel typically opens following …

In many animal cells, stimulation of cell surface receptors coupled to G proteins or tyrosine
kinases mobilizes Ca 2+ influx through store-operated Ca 2+-release-activated Ca …