Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid
hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid
structures and measuring steroid concentrations in body fluids. The molecular biology …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

Congenital adrenal hyperplasia (CAH) is a group of genetic disorders of adrenal
steroidogenesis that impair cortisol synthesis, with compensatory increases in ACTH leading …

Single-cell transcriptomics is the current gold standard for global gene expression profiling,
not only in mammals and model species, but also in non-model fish species. This is a rapidly …

Epidemiological studies have established an association between chronic exposure to PM
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …

Abstract Iron–sulfur (Fe-S) clusters are ubiquitous cofactors essential to various cellular
processes, including mitochondrial respiration, DNA repair, and iron homeostasis. A steadily …

The mitochondrial flavoprotein ferredoxin reductase (FDXR) is required for biogenesis of
iron–sulfur clusters and for steroidogenesis. Iron–sulfur (Fe–S) clusters are ubiquitous …

Cortisol is the major endocrine factor mediating the inhibitory effects of stress on vertebrate
reproduction. It is well known that cortisol affects reproduction by interacting with the …