Tropane alkaloids: chemistry, pharmacology, biosynthesis and production
KL Kohnen-Johannsen, O Kayser - Molecules, 2019 - mdpi.com
Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in
high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are …
high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are …
The scaffold-forming steps of plant alkaloid biosynthesis
BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …
privileged position in both modern and traditional medicines. In recent years, there have …
Biosynthesis of medicinal tropane alkaloids in yeast
Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for
treating neuromuscular disorders and are classified as essential medicines by the World …
treating neuromuscular disorders and are classified as essential medicines by the World …
Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …
Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces
L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …
Evolutionary history of plant metabolism
Tremendous chemical diversity is the hallmark of plants and is supported by highly complex
biochemical machinery. Plant metabolic enzymes originated and were transferred from …
biochemical machinery. Plant metabolic enzymes originated and were transferred from …
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products
B Gao, B Yang, X Feng, C Li - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 to 2020 Nitrogen heterocyclic natural products (NHNPs) are primary or
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …
Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform
BG Chavez, P Srinivasan, K Glockzin… - Proceedings of the …, 2022 - National Acad Sciences
Tropane alkaloids (TAs) are heterocyclic nitrogenous metabolites found across seven orders
of angiosperms, including Malpighiales (Erythroxylaceae) and Solanales (Solanaceae) …
of angiosperms, including Malpighiales (Erythroxylaceae) and Solanales (Solanaceae) …
A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …
central nervous system, making them crucial sources of therapeutics for neurological …
Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast
Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …