Tropane alkaloids: chemistry, pharmacology, biosynthesis and production

KL Kohnen-Johannsen, O Kayser - Molecules, 2019 - mdpi.com
Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in
high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are …

The scaffold-forming steps of plant alkaloid biosynthesis

BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Biosynthesis of medicinal tropane alkaloids in yeast

P Srinivasan, CD Smolke - Nature, 2020 - nature.com
Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for
treating neuromuscular disorders and are classified as essential medicines by the World …

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

F Zhang, F Qiu, J Zeng, Z Xu, Y Tang, T Zhao… - Nature …, 2023 - nature.com
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …

Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

Evolutionary history of plant metabolism

HA Maeda, AR Fernie - Annual Review of Plant Biology, 2021 - annualreviews.org
Tremendous chemical diversity is the hallmark of plants and is supported by highly complex
biochemical machinery. Plant metabolic enzymes originated and were transferred from …

Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products

B Gao, B Yang, X Feng, C Li - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 to 2020 Nitrogen heterocyclic natural products (NHNPs) are primary or
secondary metabolites containing nitrogen heterocyclic (N-heterocyclic) skeletons. Due to …

Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform

BG Chavez, P Srinivasan, K Glockzin… - Proceedings of the …, 2022 - National Acad Sciences
Tropane alkaloids (TAs) are heterocyclic nitrogenous metabolites found across seven orders
of angiosperms, including Malpighiales (Erythroxylaceae) and Solanales (Solanaceae) …

A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis

RS Nett, Y Dho, YY Low… - Proceedings of the …, 2021 - National Acad Sciences
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …

Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast

P Srinivasan, CD Smolke - Proceedings of the National …, 2021 - National Acad Sciences
Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …