[PDF][PDF] Metabolic flexibility: hibernation, torpor, and estivation

JF Staples - Compr Physiol, 2016 - uwo.ca
Many environmental conditions can constrain the ability of animals to obtain sufficient food
energy, or transform that food energy into useful chemical forms. To survive extended …

Immobility-associated thromboprotection is conserved across mammalian species from bear to human

M Thienel, JB Müller-Reif, Z Zhang, V Ehreiser, J Huth… - Science, 2023 - science.org
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary
embolism is a major cause of morbidity and mortality. Short-term immobility-related …

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

AL Boyd, JC Reid, KR Salci, L Aslostovar… - Nature cell …, 2017 - nature.com
Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional
leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due …

Hibernation as a tool for radiation protection in space exploration

A Puspitasari, M Cerri, A Takahashi, Y Yoshida… - Life, 2021 - mdpi.com
With new and advanced technology, human exploration has reached outside of the Earth's
boundaries. There are plans for reaching Mars and the satellites of Jupiter and Saturn, and …

Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

CTA Lewis, EG Melhedegaard, MM Ognjanovic… - Elife, 2024 - elifesciences.org
Hibernation is a period of metabolic suppression utilized by many small and large mammal
species to survive during winter periods. As the underlying cellular and molecular …

Genomic signatures of selection in bats surviving white‐nose syndrome

SA Gignoux‐Wolfsohn, ML Pinsky, K Kerwin… - Molecular …, 2021 - Wiley Online Library
Rapid evolution of advantageous traits following abrupt environmental change can help
populations recover from demographic decline. However, for many introduced diseases …

[HTML][HTML] 21st century climate change threatens on the Brown bear

A Acarer, A Mert - Cerne, 2024 - SciELO Brasil
Background: Today, the biggest threat to mammalian predators with wide distribution areas
is habitats fragmentation or changing climate conditions. We aimed to reveal the habitat …

Metabolic Changes in Summer Active and Anuric Hibernating Free-Ranging Brown Bears (Ursus arctos)

P Stenvinkel, O Fröbert, B Anderstam, F Palm… - PloS one, 2013 - journals.plos.org
The brown bear (Ursus arctos) hibernates for 5 to 6 months each winter and during this time
ingests no food or water and remains anuric and inactive. Despite these extreme conditions …

Seasonal variation in haematological and biochemical variables in free-ranging subadult brown bears (Ursus arctos) in Sweden

AR Græsli, AL Evans, Å Fahlman, MF Bertelsen… - BMC Veterinary …, 2015 - Springer
Background Free-ranging brown bears exhibit highly contrasting physiological states
throughout the year. They hibernate 6 months of the year, experiencing a decrease in body …

Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model

T Cahill, WA da Silveira, L Renaud, H Wang… - Scientific Reports, 2023 - nature.com
Mankind's quest for a manned mission to Mars is placing increased emphasis on the
development of innovative radio-protective countermeasures for long-term space travel …