Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …

Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect>
95% of adults worldwide. Despite its central role in EBV persistence and oncogenesis, much …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

Essentially all the biological functions of DNA depend on site‐specific DNA‐binding proteins
finding their targets, and therefore 'searching'through megabases of non‐target DNA. In this …

Differentiation of embryonic stem (ES) cells from a pluripotent to a committed state involves
global changes in genome expression patterns. Gene activity is critically determined by …

Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by
DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units …