Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic
necrosis and dampens inflammation. Defective efferocytosis drives important diseases …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca 2+), thought to
be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to
maintain optimal rates of ATP production, extreme levels of calcium overcoming the …