Chitin and its derivative chitosan are highly abundant polymers in nature, appearing in both
the shells and exoskeletons of various marine and non-marine species. Since they possess …

Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

For several decades there has been accumulating evidence implicating type I interferons
(IFNs) as key elements of the immune response. Therapeutic approaches incorporating …

Obesity and its associated complications are global public health concerns. Metabolic
disturbances and immune dysregulation cause adipose tissue stress and dysfunction in …

Substantial evidence indicates that microRNA-155 (miR-155) plays a crucial role in the
pathogenesis of diabetes mellitus (DM) and its complications. A number of clinical studies …

Hashimoto's thyroiditis (HT) and Graves' disease (GD) are prevalent autoimmune disorders,
representing opposite ends of the clinical spectrum of autoimmune thyroid diseases (AITD) …

Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens
and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated …

Objectives An interferon (IFN) gene signature (IGS) is present in approximately 50% of early,
treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively …

RNA acts as an immunostimulatory molecule in the innate immune system to activate
nucleic acid sensors. It functions as an intermediate, conveying genetic information to …