Locus-specific and activity-independent gene repositioning during early tumorigenesis
The mammalian genome is highly organized within the cell nucleus. The nuclear position of
many genes and genomic regions changes during physiological processes such as …
many genes and genomic regions changes during physiological processes such as …
The three‐dimensional cancer nucleus
S Mai - Genes, Chromosomes and Cancer, 2019 - Wiley Online Library
Research into the three‐dimensional (3D) organization of the cancer cell genome started
over 100 years ago. We follow an exciting avenue of research in this field, from …
over 100 years ago. We follow an exciting avenue of research in this field, from …
The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed–Sternberg cells
H Knecht, B Sawan, D Lichtensztejn, B Lemieux… - Leukemia, 2009 - nature.com
To get an insight into the transition from mononuclear Hodgkin cells (H cells) to diagnostic
multinuclear Reed–Sternberg cells (RS cells), we performed an analysis of the three …
multinuclear Reed–Sternberg cells (RS cells), we performed an analysis of the three …
Nuclear remodeling as a mechanism for genomic instability in cancer
This chapter focuses on the three-dimensional organization of the nucleus in normal, early
genomically unstable, and tumor cells. A cause–consequence relationship is discussed …
genomically unstable, and tumor cells. A cause–consequence relationship is discussed …
LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates
V Lajoie, B Lemieux, B Sawan… - Blood, The Journal …, 2015 - ashpublications.org
Hodgkin lymphoma (HL) and Burkitt lymphoma are both germinal center–derived B-cell
lymphomas. To assess the consequences of permanent latent membrane protein 1 (LMP1) …
lymphomas. To assess the consequences of permanent latent membrane protein 1 (LMP1) …
Three-dimensional telomere signatures of Hodgkin-and Reed-Sternberg cells at diagnosis identify patients with poor response to conventional chemotherapy
In classic Hodgkin lymphoma (HL) the malignant mononuclear Hodgkin (H) and
multinuclear Reed-Sternberg (RS) cells are characterized by a distinct three-dimensional …
multinuclear Reed-Sternberg (RS) cells are characterized by a distinct three-dimensional …
3D Telomere FISH defines LMP1-expressing Reed–Sternberg cells as end-stage cells with telomere-poor 'ghost'nuclei and very short telomeres
H Knecht, B Sawan, Z Lichtensztejn… - Laboratory …, 2010 - nature.com
Abstract In Epstein–Barr virus (EBV) negative Hodgkin's cell lines and classical EBV-
negative Hodgkin's lymphoma (HL), Reed–Sternberg cells (RS cells) represent end-stage …
negative Hodgkin's lymphoma (HL), Reed–Sternberg cells (RS cells) represent end-stage …
[HTML][HTML] Analysis by TeloView® Technology Predicts the Response of Hodgkin's Lymphoma to First-Line ABVD Therapy
Simple Summary Three-dimensional (3D) telomere analysis using TeloView v 2.2 has
shown promise in quantifying genomic instability and predicting therapy response. In a study …
shown promise in quantifying genomic instability and predicting therapy response. In a study …
Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus
Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent
mechanism of gene inactivation in cancer. There is great interest in dissecting the …
mechanism of gene inactivation in cancer. There is great interest in dissecting the …
c-Myc—Dependent Formation of Robertsonian Translocation Chromosomes in Mouse Cells
A Guffei, Z Lichtensztejn, A Gonçlves, S Silva, SF Louis… - Neoplasia, 2007 - Elsevier
Robertsonian (Rb) translocation chromosomes occur in human and murine cancers and
involve the aberrant joining of two acrocentric chromosomes in humans and two telocentric …
involve the aberrant joining of two acrocentric chromosomes in humans and two telocentric …