Management of frailty: opportunities, challenges, and future directions

E Dent, FC Martin, H Bergman, J Woo… - The Lancet, 2019 - thelancet.com
Frailty is a complex age-related clinical condition characterised by a decline in physiological
capacity across several organ systems, with a resultant increased susceptibility to stressors …

The physical frailty syndrome as a transition from homeostatic symphony to cacophony

LP Fried, AA Cohen, QL Xue, J Walston… - Nature aging, 2021 - nature.com
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

A multidimensional approach to frailty in older people

A Pilotto, C Custodero, S Maggi, MC Polidori… - Ageing research …, 2020 - Elsevier
Frailty is an important factor determining a higher risk of adverse health outcomes in older
adults. Although scientific community in the last two decades put a lot of effort for its …

Screening for and managing the person with frailty in primary care: ICFSR consensus guidelines

JG Ruiz, E Dent, JE Morley, RA Merchant… - The journal of nutrition …, 2020 - Springer
1. Geriatric Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA; 2.
Torrens University of Australia, Adelaide and Baker Heart and Diabetes Institute, Melbourne …

Association between patient frailty and postoperative mortality across multiple noncardiac surgical specialties

EL George, DE Hall, A Youk, R Chen, A Kashikar… - JAMA …, 2021 - jamanetwork.com
Importance Frailty is an important risk factor for postoperative mortality. Whether the
association between frailty and mortality is consistent across all surgical specialties …

[HTML][HTML] Frailty and comprehensive geriatric assessment

H Lee, E Lee, IY Jang - Journal of Korean medical science, 2020 - synapse.koreamed.org
Frailty is defined as a reduced physiologic reserve vulnerable to external stressors. For older
individuals, frailty plays a decisive role in increasing adverse health outcomes in most …

The association of frailty with outcomes after cancer surgery: a systematic review and metaanalysis

JF Shaw, D Budiansky, F Sharif, DI McIsaac - Annals of Surgical Oncology, 2022 - Springer
Background Cancer is common in older adults, who often have concurrent frailty. Frailty is a
strong predictor of adverse outcomes in surgical patients. Our objective is to systematically …

Frailty in critical care medicine: a review

JC De Biasio, AM Mittel, AL Mueller… - Anesthesia & …, 2020 - journals.lww.com
Traditional approaches to clinical risk assessment utilize age as a marker of increased
vulnerability to stress. Relatively recent advancements in the study of aging have led to the …

Association of routine preoperative frailty assessment with 1-year postoperative mortality

PR Varley, D Buchanan, A Bilderback… - JAMA …, 2023 - jamanetwork.com
Importance Patient frailty is a known risk factor for adverse outcomes following surgery, but
data are limited regarding whether systemwide interventions related to frailty are associated …

Frailty, a multisystem ageing syndrome

J Thillainadesan, IA Scott, DG Le Couteur - Age and ageing, 2020 - academic.oup.com
The management of frail older people is a key component of aged care. There has been a
plethora of tools developed for the diagnosis and screening of frailty. Some of these tools …