Mechanism of neurotransmitter release coming into focus
J Rizo - Protein Science, 2018 - Wiley Online Library
Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …
Single-vesicle assays using liposomes and cell-derived vesicles: from modeling complex membrane processes to synthetic biology and biomedical applications
The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …
contradistinction to the extracellular environment. The plasma membrane not only serves as …
Widespread occurrence of the droplet state of proteins in the human proteome
A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor
attachment protein receptor) proteins mediate evoked synchronous neurotransmitter …
attachment protein receptor) proteins mediate evoked synchronous neurotransmitter …
Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18
Y Lai, UB Choi, J Leitz, HJ Rhee, C Lee, B Altas… - Neuron, 2017 - cell.com
Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …
Molecular mechanisms of fast neurotransmitter release
AT Brunger, UB Choi, Y Lai, J Leitz… - Annual review of …, 2018 - annualreviews.org
This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …
Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy
L Cui, H Li, Y ** and activation function
M Bera, S Ramakrishnan, J Coleman… - Elife, 2022 - elifesciences.org
Previously we reported that Synaptotagmin-1 and Complexin synergistically clamp the
SNARE assembly process to generate and maintain a pool of docked vesicles that fuse …
SNARE assembly process to generate and maintain a pool of docked vesicles that fuse …
Intrinsically disordered proteins in synaptic vesicle trafficking and release
The past few years have resulted in an increased awareness and recognition of the
prevalence and roles of intrinsically disordered proteins and protein regions (IDPs and IDRs …
prevalence and roles of intrinsically disordered proteins and protein regions (IDPs and IDRs …