The history of antiretrovirals: key discoveries over the past 25 years
E De Clercq - Reviews in medical virology, 2009 - Wiley Online Library
Abstract Within 25 years after zidovudine (3′‐azido‐2′, 3′‐dideoxythymidine, AZT) was
first described as an inhibitor of HIV replication, 25 anti‐HIV drugs have been formally …
first described as an inhibitor of HIV replication, 25 anti‐HIV drugs have been formally …
Novel approaches in fighting herpes simplex virus infections
SS Wilson, E Fakioglu, BC Herold - Expert review of anti-infective …, 2009 - Taylor & Francis
The development of novel strategies to eradicate herpes simplex virus (HSV) is a global
public health priority. While acyclovir and related nucleoside analogues provide successful …
public health priority. While acyclovir and related nucleoside analogues provide successful …
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
SK Lai, YY Wang, K Hida, R Cone… - Proceedings of the …, 2010 - National Acad Sciences
The mechanisms by which mucus helps prevent viruses from infecting mucosal surfaces are
not well understood. We engineered non-mucoadhesive nanoparticles of various sizes and …
not well understood. We engineered non-mucoadhesive nanoparticles of various sizes and …
Structure activity relationship of dendrimer microbicides with dual action antiviral activity
D Tyssen, SA Henderson, A Johnson, J Sterjovski… - PloS one, 2010 - journals.plos.org
Background Topical microbicides, used by women to prevent the transmission of HIV and
other sexually transmitted infections are urgently required. Dendrimers are highly branched …
other sexually transmitted infections are urgently required. Dendrimers are highly branched …
Griffithsin protects mice from genital herpes by preventing cell-to-cell spread
Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent
HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical …
HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical …
Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate
JC Kouokam, D Huskens, D Schols, A Johannemann… - Plos one, 2011 - journals.plos.org
Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have
potent in vitro activity against viruses that display dense clusters of oligomannose N-linked …
potent in vitro activity against viruses that display dense clusters of oligomannose N-linked …
Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system
Topical pre-exposure prophylaxis (PrEP) with antiretroviral drugs holds promise in
preventing vaginal transmission of HIV. However, significant biomedical and social issues …
preventing vaginal transmission of HIV. However, significant biomedical and social issues …
Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity
Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid
in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the …
in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the …
Fractional CO2 laser for genitourinary syndrome of menopause in breast cancer survivors: clinical, immunological, and microbiological aspects
A Becorpi, G Campisciano, N Zanotta, Z Tredici… - Lasers in medical …, 2018 - Springer
The composition of vaginal microbiome in menopause and cancer survivor women changes
dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of …
dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of …
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
Background The lack of biomarkers that are predictive of safety is a critical gap in the
development of microbicides. The present experiments were designed to evaluate the …
development of microbicides. The present experiments were designed to evaluate the …