Mental disorders are a significant cause of disability worldwide. They profoundly affect
individuals' well-being and impose a substantial financial burden on societies and …

Animal experimentation in the Parkinson's disease (PD) field is a classic example of how the
use of animal models to study diseases can have a significant impact on human health …

Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression
of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To …

Since the 1980s, we have witnessed the rapid development of genetically modified mouse
models of human diseases. A large number of transgenic and knockout mice have been …

Background Traditionally, in biomedical animal research, laboratory rodents are individually
examined in test apparatuses outside of their home cages at selected time points. However …

Animal models of neurodegenerative and neuropsychiatric disorders require extensive
behavioral phenoty**. Currently, this presents several caveats and the most important …

An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …

A large variety of rodent behavioral tests are currently being used to evaluate traits such as
sensory-motor function, social interactions, anxiety-like and depressive-like behavior …

An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of
nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off …

Social behaviour has a key role in animal survival across species, ranging from insects to
primates and humans. However, the biological mechanisms driving natural interactions …