The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

Summary Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …

Identification of mechanisms that program early effector T cells to either terminal effector T
(Teff) or memory T (Tm) cells has important implications for protective immunity against …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Abstract Interleukin-2 (IL-2) signals influence various lymphocyte subsets during
differentiation, immune responses and homeostasis. As discussed in this Review …

The liver provides a tolerogenic immune niche exploited by several highly prevalent
pathogens as well as by primary and metastatic tumors. We have sampled healthy and …

Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …

Host defense against viruses and intracellular parasites depends on effector CD8+ T cells,
whose optimal clonal expansion, differentiation, and memory properties require signals from …

Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to
correlate with proliferative capacity or effector function. Here we demonstrate that the …