The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

Modern cancer therapy has successfully cured many cancers and converted a terminal
illness into a chronic disease. Because cancer patients often have coexisting heart …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

For more than 50 years, investigators have considered a malignant stem cell as the potential
origin of and a key therapeutic target for acute myeloid leukemia (AML) and other forms of …

Background No effective systemic therapy exists for patients with advanced hepatocellular
carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the …

Background We conducted a phase 3, randomized, double-blind, placebo-controlled trial of
sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients …

Cancer treatment today employs a combination of chemotherapy, radiotherapy, and surgery
to prolong life and provide cure. However, many of these treatments can cause …

Purpose: We initiated a personalized medicine program in the context of early clinical trials,
using targeted agents matched with tumor molecular aberrations. Herein, we report our …

Since the molecular revolution of the 1980s, knowledge of the aetiology of cancer has
increased considerably, which has led to the discovery and development of targeted …

Although patients with advanced refractory solid tumors have poor prognosis, the clinical
development of targeted protein kinase inhibitors offers hope for the future treatment of many …