All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

Mechanisms controlling the emergence of lethal neuroendocrine prostate cancer (NEPC),
especially those that are consequences of treatment-induced suppression of the androgen …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

So far, two genes associated with familial melanoma have been identified, accounting for a
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …

The development and progression of melanoma have been attributed to independent or
combined genetic and epigenetic events. There has been remarkable progress in …

Protein-coding genes account for only a small part of the human genome, whereas the vast
majority of transcripts make up the non-coding RNAs including long non-coding RNAs …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

During embryonic development in vertebrates, the neural crest‐derived melanoblasts
migrate along the dorsolateral axis and cross the basal membrane separating the dermis …