Systems, methods, and workflows for optogenetics analysis

AE Cohen, J Kralj, AD Douglass… - US Patent 9,702,874, 2017 - Google Patents
5,290,699 A 3, 1994 Oesterhelt et al. 5,661,035 A 8, 1997 Tsien et al. 5,925,523 A 7, 1999
Dove et al. 6,107,066 A 8, 2000 Tsien et al. 6,200,759 B1 3, 2001 Dove et al. 6,243,197 B1 …

Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2016 - Google Patents
2015-07-02 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Optogenetic probes for measuring membrane potential

AE Cohen, J Kralj, AD Douglass - US Patent 9,791,455, 2017 - Google Patents
2015-07-01 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Optical selection of cells

AE Cohen, MP Chien - US Patent 10,077,463, 2018 - Google Patents
5, 925, 523 A 7/1999 Dove et al. 6, 107, 066 A 8/2000 Tsien et al. 6, 200, 759 B1 3/2001
Dove et al. 6, 243, 197 B1 6/2001 Schalz 6, 885, 492 B2 4/2005 DeSimone et al. 6, 898, 004 …

Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2019 - Google Patents
Provided herein are variants of an archaerhodopsin useful for application such as optical
measurement of membrane potential. The present invention also relates to polynucleotides …

Systems, methods, and workflows for optogenetics analysis

AE Cohen, J Kralj, AD Douglass… - US Patent 10,161,937, 2018 - Google Patents
The invention provides methods for characterizing cellular physiology by incorporating into
an electrically excitable cell an optical reporter of, and an optical actuator of, electrical …

Optogenetic probes for measuring membrane potential

AE Cohen, J Kralj, AD Douglass - US Patent 10,352,945, 2019 - Google Patents
2018-02-21 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Scanning laser microscope

H Kitagawa - US Patent 9,696,532, 2017 - Google Patents
An image having an expected Superresolution effect is created in a straightforward manner
and with Superior pre cision. The invention provides a scanning laser microscope including …

Optogenetic probes for measuring membrane potential

AE Cohen, D Hochbaum, P Zou, SL Farhi… - US Patent …, 2020 - Google Patents
Provided herein are variants of an archaerhodopsin useful for application such as optical
measurement of membrane potential. The present invention also relates to polynucleotides …

Phase cancellation microscopy

PTC So, Z Yaqoob, D Lyzwa, V Singh… - US Patent …, 2022 - Google Patents
Our high phase sensitivity wide-field phase cancellation interferometry system allows single-
shot, label-free optical sensing of neural action potentials via imaging of optical path length …