Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANCs) are the
proximal cause of an action potential. Each individual channel type has been thoroughly …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Background—Intergenic variations on chromosome 4q25, close to the PITX2 transcription
factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult …

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, often coexists with
the related arrhythmia atrial flutter (AFL). Limitations in effectiveness and safety of current …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …

It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of
the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate …

Genome-wide association studies have uncovered over a 100 genetic loci associated with
atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …