Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host
shutoff factor, suppresses host innate immune functions. By combining cryo-electron …

Coronavirus genome replication is associated with virus-induced cytosolic double-
membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis …

The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here
we combined recent developments in cryo–electron tomography (cryo-ET) to produce three …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes translate genetic information into primary structure. During translation, various
cofactors transiently bind to the ribosome that undergoes prominent conformational and …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …