The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health
and muscle regeneration. While prior research unveiled the structural versatility of APJR in …

G protein-coupled receptors (GPCRs) are dynamic membrane receptors that transduce
extracellular signals to the cell interior via a ligand–receptor-effector (ternary) complex that …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in
humans, playing a crucial role in regulating diverse cellular processes and serving as …

Background Vascular calcification is a crucial pathophysiological process associated with
age-related cardiovascular diseases. Elabela, a recently identified peptide, has emerged as …

We describe a structural and functional study of the G protein-coupled apelin receptor, which
binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate …

Abstract Aldehyde dehydrogenase 2 (ALDH2), a pivotal enzyme in the metabolism of toxic
aldehydes produced by oxidative stress, has been demonstrated to play a cardioprotective …

It has been challenging to determine how a ligand that binds to a receptor activates
downstream signaling pathways and to predict the strength of signaling. The challenge is …

Angiotensin II protein J receptor, APJ, is a type AG protein coupled receptor. Endogenous
apelin and elabela peptides stimulate APJ via distinct signalling profiles. A complex …

Background. Peptidergic GPCR systems are broadly distributed in the human body and
regulate numerous physiological processes by activating complex networks of intracellular …

The future of G protein‐coupled receptor therapeutics: Apelin receptor acts as a prototype for
the advancement of precision drug design - PMC Skip to main content Here's how you know …