The degradation of cartilage in the human body is impacted by aging, disease, genetic
predisposition and continued insults resulting from daily activity. The burden of cartilage …

The intervertebral disc (IVD) is a moderately moving joint that is located between the bony
vertebrae and provides flexibility and load transmission throughout the spinal column. The …

Low back pain is a major physical and socioeconomic problem. Degeneration of the
intervertebral disc and especially that of nucleus pulposus (NP) has been linked to low back …

The extent of ageing in the musculoskeletal system during the life course affects the quality
and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed …

Study Design. An in vivo study to assess the differentiation status of mesenchymal stem cells
(MSCs) transplanted to the nucleus pulposus of degenerative discs in a rabbit model …

Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of
the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration …

Purpose Mechanical loading represents an integral part of intervertebral disc (IVD)
homeostasis. This review aims to summarise recent knowledge on the effects of mechanical …

Objective. Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we
ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype …

Study Design. In vitro measurements of metabolic rates of isolated bovine nucleus pulposus
cells at varying levels of oxygen, glucose, and pH. Objectives. To obtain quantitative …

Lumbar intervertebral discs (IVDs) are prone to degeneration upon skeletal maturity. In fact,
this process could explain approximately 40% of the cases of low back pain in humans …