Cardiac energy metabolism in heart failure
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …
the energy metabolic changes that occur in heart failure are complex and are dependent not …
Mechanisms of physiological and pathological cardiac hypertrophy
M Nakamura, J Sadoshima - Nature Reviews Cardiology, 2018 - nature.com
Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …
Ceramides and other sphingolipids as drivers of cardiovascular disease
Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging
Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …
Metabolic remodelling in heart failure
The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …
Sphingolipids in metabolic disease: The good, the bad, and the unknown
The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …
recent addition to the lipids accumulated in obesity and have emerged as important …
Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure
Background—The failing human heart is characterized by metabolic abnormalities, but
these defects remains incompletely understood. In animal models of heart failure there is a …
these defects remains incompletely understood. In animal models of heart failure there is a …
Lipid droplets in cancer: guardians of fat in a stressful world
T Petan, E Jarc, M Jusović - Molecules, 2018 - mdpi.com
Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …
Their survival during severe nutrient and oxidative stress depends on their capacity to …