Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …

Background Development of human cancer can proceed through the accumulation of
different genetic changes affecting the structure and function of the genome. Combined …

Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …

The epigenetic regulation of microRNAs is one of several mechanisms underlying
carcinogenesis. We found that microRNA-195 (miR-195) and microRNA-378 (miR-378) …

DNA methylation plays a crucial role in the establishment of tissue-specific gene expression
and the regulation of key biological processes. However, our present inability to predict the …

Background Determination of genome-wide DNA methylation is significant for both basic
research and drug development. As a key epigenetic modification, this biochemical process …

Epigenetic modifications are important in the normal functioning of the cell, from regulating
dynamic expression of essential genes and associated proteins to repressing those that are …

Global DNA hypomethylation potentially leading to pro-atherogenic gene expression occurs
in atherosclerotic lesions. However, limited information is available on the genomic location …

DNA methylation is an important biochemical process, and it has a close connection with
many types of cancer. Research about DNA methylation can help us to understand the …

DNA methylation is an inheritable chemical modification of cytosine, and represents one of
the most important epigenetic events. Computational prediction of the DNA methylation …