The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q **ong, Z **… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
The proteins of mRNA modification: writers, readers, and erasers
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
[HTML][HTML] RNA methylation and cancer treatment
To this date, over 100 different types of RNA modification have been identified. Methylation
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Y Huang, J Yan, Q Li, J Li, S Gong, H Zhou… - Nucleic acids …, 2015 - academic.oup.com
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5,
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment
Recent research suggests that increased adiposity is associated with poor cognitive
performance, independently of associated medical conditions. The evidence regarding this …
performance, independently of associated medical conditions. The evidence regarding this …
RNA methylations in human cancers
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …
regulating various biological processes, such as RNA transcription, splicing, structure …
The birth of the Epitranscriptome: deciphering the function of RNA modifications
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates
FTO demethylates internal N 6-methyladenosine (m6A) and N 6, 2′-O-dimethyladenosine
(m6Am; at the cap+ 1 position) in mRNA, m6A and m6Am in snRNA, and N 1 …
(m6Am; at the cap+ 1 position) in mRNA, m6A and m6Am in snRNA, and N 1 …
Obesity and ageing: Two sides of the same coin
Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …
Down-regulation of m6A mRNA methylation is involved in dopaminergic neuronal death
X Chen, C Yu, M Guo, X Zheng, S Ali… - ACS chemical …, 2019 - ACS Publications
N 6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the
mRNA of eukaryotes and plays a vital role in the post-transcriptional regulation. Recent …
mRNA of eukaryotes and plays a vital role in the post-transcriptional regulation. Recent …