Cells are covered by a surface layer of glycans that is referred to as the 'glycocalyx'. In this
review, we focus on the role of the glycocalyx in vascular diseases (atherosclerosis, stroke …

Esophageal cancer is a deadly disease, ranking sixth among all cancers in mortality.
Despite incremental advances in diagnostics and therapeutics, esophageal cancer still …

Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …

Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44
are crucial events that regulate the onset and progression of tumors. The intracellular …

Pancreatic ductal adenocarcinoma (PDAC) remains the most deadly disease worldwide,
with the lowest survival rate among all cancer types. Recent evidence suggests that …

Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer.
The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer …

Hyaluronic acid or hyaluronan (HA) is perhaps one of the most uncomplicated large
polymers that regulates several normal physiological processes and, at the same time …

Hyaluronan accumulates in the stroma of several solid tumors and promotes their
progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a …

Cancer‐associated fibroblasts (CAF) are a heterogeneous cell population within the tumor
microenvironment, and play an important role in tumor development. By regulating the …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …