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Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …
the development of mesoporous materials, their different synthetic routes and their use as …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
Applications of nanotechnology in plant growth and crop protection: a review
In the era of climate change, global agricultural systems are facing numerous,
unprecedented challenges. In order to achieve food security, advanced nano-engineering is …
unprecedented challenges. In order to achieve food security, advanced nano-engineering is …
Nanoparticle delivery of CRISPR/Cas9 for genome editing
L Duan, K Ouyang, X Xu, L Xu, C Wen, X Zhou… - Frontiers in …, 2021 - frontiersin.org
The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-
associated system (Cas) gene-editing system represents a promising tool for genome …
associated system (Cas) gene-editing system represents a promising tool for genome …
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - pmc.ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …
however, the translation of this biotechnology into therapy has been hindered by efficient …
Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders
E Tan, T Wan, Q Pan, J Duan, S Zhang, R Wang… - Science …, 2024 - science.org
Develo** protein drugs that can target intracellular sites remains a challenge due to their
inadequate membrane permeability. Efficient carriers for cytosolic protein delivery are …
inadequate membrane permeability. Efficient carriers for cytosolic protein delivery are …
CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
mRNA nanomedicine: Design and recent applications
The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …
key successes in the clinical management of human diseases. mRNA technology allows for …