Recently, in silico techniques have gained tremendous popularity in the field of small
molecule drug discovery. The computational jobs include not only hit generation, lead …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Five-membered heteroaromatic rings, in particular, have gained prominence in medicinal
chemistry as they offer enhanced metabolic stability, solubility and bioavailability, crucial …

Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …

The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …

Histone deacetylases (HDACs) remove acetyl groups from acetylated lysine residues and
have a large variety of substrates and interaction partners. Therefore, it is not surprising that …

Class I histone deacetylases (HDACs) are promising targets for epigenetic therapies for a
range of diseases such as cancers, inflammations, infections and neurological diseases …

Epigenetics plays a fundamental role in cancer progression, and develo** agents that
regulate epigenetics is crucial for cancer management. Among Class I and Class II HDACs …

A series of novel indole-thiazolidinedione hybrid analogues (7a to 7 u) were synthesised,
characterised and evaluated for their potential Pancreatic Lipase (PL) inhibition. Amongst …