Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …

Background Recent studies have shown that multidrug resistance may be induced by the
high stemness of cancer cells. Following prolonged chemotherapy, MDR protein 1 (MDR1) …

The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process,
which plays a critical role in embryonic development, wound healing, tissue regeneration …

Resveratrol, a safe and multi-targeted agent, has been associated with suppression of
survival, proliferation and metastasis of cancer, however, the underlying mechanisms for its …

Background: Tumor microenvironment (TME) has a pivotal impact on tumor progression,
and epithelial-mesenchymal transition (EMT) is an extremely crucial initial event in the …

Abstract Tumor‑associated macrophages/M2‑type (TAM/M2) play a key role in the
metastasis and angiogenesis of cancer, and are considered to be critical targets for cancer …

Spherical cultures (SCs) can be regarded in cancer research as a link between in vitro
investigations on cancer lines and in vivo studies of tumor development. SCs are believed to …

The extracellular matrix (ECM) affects cell behaviors, such as survival, proliferation, motility,
invasion, and differentiation. The arginine-glycine-aspartic acid (RGD) sequence is present …

Background Colorectal cancer is the second most common cause of cancer‐related death
worldwide and standardized therapies often fail to treat the more aggressive and …