Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

Studies using kainate, an excitatory amino acid extracted from a seaweed, have provided
major contributions to the understanding of epileptogenesis. Here we review pioneering and …

Local-circuit, γ-aminobutyric acid-releasing inhibitory interneurons of the hippocampus and
cortex have traditionally been considered as the regulators of principal neuron activity—the …

Two decades have passed since the first report of the cloning of a kainate-type glutamate
receptor (KAR) subunit. The intervening years have seen a rapid growth in our …

Functional kainate receptors are ubiquitous in the central nervous system. After a search for
their functional significance, a considerable amount of data indicates that this class of …

Excitatory glutamatergic transmission involves a variety of different receptor types, each with
distinct properties and functions. Physiological studies have identified both post-and …

Kainate receptors alter the excitability of mossy fiber axons and have been reported to play a
role in the induction of long-term potentiation (LTP) at mossy fiber synapses in the …

A decade ago, our understanding of the molecular properties of kainate receptors and their
involvement in synaptic physiology was essentially null. A plethora of recent studies has …

Exogenous kainate receptor agonists have been shown to modulate inhibitory synaptic
transmission in the hippocampus, but the pathways involved in physiological activation of …