The role of early biologic therapy in inflammatory bowel disease

DR Berg, JF Colombel, R Ungaro - Inflammatory bowel diseases, 2019 - academic.oup.com
The goals for treatment of inflammatory bowel diseases (IBDs) are changing from
elimination of symptoms toward complete disease control—a process that demands both …

Detecting shared pathogenesis from the shared genetics of immune-related diseases

A Zhernakova, CC Van Diemen… - Nature Reviews Genetics, 2009 - nature.com
Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

Meta-rppg: Remote heart rate estimation using a transductive meta-learner

E Lee, E Chen, CY Lee - Computer Vision–ECCV 2020: 16th European …, 2020 - Springer
Remote heart rate estimation is the measurement of heart rate without any physical contact
with the subject and is accomplished using remote photoplethysmography (rPPG) in this …

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

JC Lee, D Biasci, R Roberts, RB Gearry, JC Mansfield… - Nature …, 2017 - nature.com
For most immune-mediated diseases, the main determinant of patient well-being is not the
diagnosis itself but instead the course that the disease takes over time (prognosis) …

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

I Cleynen, JR González, C Figueroa, A Franke… - Gut, 2013 - gut.bmj.com
Objective Through genome-wide association scans and meta-analyses thereof, over 70
genetic loci (Crohn's disease (CD) single nucleotide polymorphisms (SNPs)) are …

Diversity of intestinal macrophages in inflammatory bowel diseases

AA Kühl, U Erben, LI Kredel, B Siegmund - Frontiers in immunology, 2015 - frontiersin.org
Macrophages as innate immune cells and fast responders to antigens play a central role in
protecting the body from the luminal content at a huge interface. Chronic inflammation in …

[HTML][HTML] A double-edged sword: DLG5 in diseases

X Song, Q Li, J Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Discs large homolog 5 (DLG5), a key member of the membrane-associated
guanylate kinase (MAGUKs) family, is a scaffold molecule for signal transduction complexes …

Predicting outcomes to optimize disease management in inflammatory bowel diseases

J Torres, F Caprioli, KH Katsanos… - Journal of Crohn's …, 2016 - academic.oup.com
Abstract Background and Aims: Efforts to slow or prevent the progressive course of
inflammatory bowel diseases [IBD] include early and intensive monitoring and treatment of …

A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease

EAM Festen, P Goyette, T Green, G Boucher… - PLoS …, 2011 - journals.plos.org
Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory
diseases, involving genetic and environmental factors in their pathogenesis. The two …

How to predict clinical relapse in inflammatory bowel disease patients

E Liverani, E Scaioli, RJ Digby… - World journal of …, 2016 - pmc.ncbi.nlm.nih.gov
Inflammatory bowel diseases have a natural course characterized by alternating periods of
remission and relapse. Disease flares occur in a random way and are currently …