Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Acute respiratory distress syndrome

KD Wick, LB Ware, MA Matthay - bmj, 2024 - bmj.com
The understanding of acute respiratory distress syndrome (ARDS) has evolved greatly since
it was first described in a 1967 case series, with several subsequent updates to the definition …

Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis: a narrative review

R Cusack, LD Bos, P Povoa, I Martin-Loeches - Frontiers in Medicine, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a severe organ failure occurring mainly in
critically ill patients as a result of different types of insults such as sepsis, trauma or …

[HTML][HTML] The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome

AN Rizzo, EP Schmidt - American Journal of Physiology …, 2023 - journals.physiology.org
The alveolar epithelial glycocalyx is a dense anionic layer of glycosaminoglycans (GAGs)
and proteoglycans that lines the apical surface of the alveolar epithelium. In contrast to the …

The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia

C Langouët-Astrié, K Oshima, SA McMurtry, Y Yang… - Cell reports, 2022 - cell.com
Influenza infection is substantially worsened by the onset of secondary pneumonia caused
by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional …

N‐Acetylcysteine and Other Sulfur‐Donors as a Preventative and Adjunct Therapy for COVID‐19

HN du Preez, C Aldous, HG Kruger… - Advances in …, 2022 - Wiley Online Library
The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

Advancing precision medicine for the diagnosis and treatment of acute respiratory distress syndrome

AN Rizzo, NR Aggarwal, BT Thompson… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of
respiratory failure. Despite decades of research, there are no effective pharmacologic …

[HTML][HTML] New insights into the alveolar epithelium as a driver of acute respiratory distress syndrome

M Sanches Santos Rizzo Zuttion, SKL Moore, P Chen… - Biomolecules, 2022 - mdpi.com
The alveolar epithelium serves as a barrier between the body and the external environment.
To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and …

[HTML][HTML] Engineering of pulmonary surfactant corona on inhaled nanoparticles to operate in the lung system

M Falahati, A Hasan, HA Zeinabad, V Serpooshan… - Nano Today, 2023 - Elsevier
Exposure of inhaled nanoparticles (NPs) to the deep lung tissue results in the adsorption of
pulmonary surfactant (PSf) on the surface of NPs and the formation of a biomolecular …