Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function

S Comità, S Femmino, C Thairi, G Alloatti… - Basic research in …, 2021 - Springer
Ischemia–reperfusion injury (IRI) is one of the biggest challenges for cardiovascular
researchers given the huge death toll caused by myocardial ischemic disease …

Pivotal importance of STAT3 in protecting the heart from acute and chronic stress: new advancement and unresolved issues

FA Zouein, R Altara, Q Chen, EJ Lesnefsky… - Frontiers in …, 2015 - frontiersin.org
The transcription factor, signal transducer and activator of transcription 3 (STAT3), has been
implicated in protecting the heart from acute ischemic injury under both basal conditions and …

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury

TA Yakulov, AP Todkar, K Slanchev, J Wiegel… - Nature …, 2018 - nature.com
Kidney injury is a common complication of severe disease. Here, we report that injuries of
the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in …

HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling

WF Cai, L Jiang, J Liang, S Dutta, W Huang… - Stem Cell Reviews and …, 2024 - Springer
Although stem/progenitor cell therapy shows potential for myocardial infarction repair,
enhancing the therapeutic efficacy could be achieved through additional genetic …

Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant

GS Liu, H Zhu, WF Cai, X Wang, M Jiang, K Essandoh… - Autophagy, 2018 - Taylor & Francis
ABSTRACT HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a
novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 …

Methionine Sulfoxide Reductase A Deficiency Exacerbates Cisplatin-Induced Nephrotoxicity via Increased Mitochondrial Damage and Renal Cell Death

MR Noh, KY Kim, SJ Han, JI Kim, HY Kim… - Antioxidants & redox …, 2017 - liebertpub.com
Aims: Methionine sulfoxide reductase A (MsrA), which is abundantly localized in the
mitochondria, reduces methionine-S-sulfoxide, scavenging reactive oxygen species (ROS) …

Stromal cell‐derived factor‐1 enhances the therapeutic effects of human endometrial regenerative cells in a mouse sepsis model

W **, Y Zhao, Y Hu, D Yu, X Li, Y Qin… - Stem cells …, 2020 - Wiley Online Library
Endometrial regenerative cells (ERCs) are mesenchymal‐like stromal cells obtained from
human menstrual blood, whose positive therapeutic effects have been validated in several …

Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity

C Sun, X Zhang, F Yu, C Liu, F Hu… - Journal of …, 2021 - journals.sagepub.com
Objective Myocardial ischemia/reperfusion (I/R) injury causes various severe heart
diseases, including myocardial infarction. This study aimed to determine the therapeutic …

Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts

KH Park, X He, L Jiang, H Zhu, J Liang, Y Wang… - Stem Cell Reviews and …, 2023 - Springer
Abstract Background and Objective Our previous studies demonstrated that MG53 protein
can protect the myocardium, but its use as a therapeutic is challenging due to its short half …

Multi-Omics Analysis of Diabetic Heart Disease in the db/db Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene

A Faulkner, Z Dang, E Avolio, AC Thomas, T Batstone… - Cells, 2020 - mdpi.com
Characterisation of animal models of diabetic cardiomyopathy may help unravel new
molecular targets for therapy. Long-living individuals are protected from the adverse …