The nucleosome, which is the primary building block of chromatin, is not a static structure: It
can adopt alternative conformations. Changes in solution conditions or changes in histone …

The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation,
and repression by histone acetylation and deacetylation has shed light on the role of histone …

The yeast Sir2 protein, required for transcriptional silencing, has an NAD+-dependent
histone deacetylase (HDA) activity. Yeast extracts contain a NAD+-dependent HDA activity …

The enzyme UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase (LpxC) catalyzes the
committed step in the biosynthesis of lipid A and is therefore a potential antibiotic target …

L'acétylation des histones, découverte il ya plus de 40 ans, est une modification réversible
des résidus lysine dans le domaine N terminal des histones du coeur. Les domaines N …

Histone acetylation is maintained through the action of histone acetyltransferases and
deacetylases and has been correlated with increased gene activity. To investigate the …

The present invention concerns the discovery that proteins encoded by a family of genes,
termed here HDX-related genes, which are involved in the control of chromatin Structure …

The invention relates to the inhibition of histone deacety lase. The invention provides
compounds and methods for inhibiting histone deacetylase enzymatic activity. The inven …

The nuclear matrix, the RNA-protein skeleton of the nucleus, has a role in the organization
and function of nuclear DNA. Nuclear processes associated with the nuclear matrix include …

The importance of control of the levels of histone acetylation for the control of gene
expression in eukaryotic chromatin is being elucidated, and the yeast Saccharomyces …