Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the
treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …

Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during
inflammation and tissue remodelling and in many human cancers, in which it frequently …

Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes …

The plasminogen system has been implicated in clot lysis, wound healing, tissue
regeneration, cancer and many other processes that affect health and disease. The …

soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and
elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in …

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …