Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …

In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

The plant Cannabis sativa, commonly called cannabis or marijuana, has been used for its
psychotropic and mind-altering side effects for millennia. There has been growing attention …

In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

Despite their widespread Internet availability and use, many of the new drugs of abuse
remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

The brain's reward circuitry consists of an “in series” circuit of dopaminergic (DA) neurons in
the ventral tegmental area (VTA), nucleus accumbens (Acb), and that portion of the medial …

New psychoactive substances (NPS) are a heterogeneous and rapidly evolving class of
molecules available on the global illicit drug market (eg smart shops, internet,“dark net”) as a …