Prognostic and predictive biomarker developments in multiple myeloma
CT Wallington-Beddoe, RL Mynott - Journal of hematology & oncology, 2021 - Springer
New approaches to stratify multiple myeloma patients based on prognosis and therapeutic
decision-making, or prediction, are needed since patients are currently managed in a similar …
decision-making, or prediction, are needed since patients are currently managed in a similar …
IMWG consensus on risk stratification in multiple myeloma
Multiple myeloma is characterized by underlying clinical and biological heterogeneity, which
translates to variable response to treatment and outcome. With the recent increase in …
translates to variable response to treatment and outcome. With the recent increase in …
The genetic architecture of multiple myeloma
Based on the clinical features of myeloma and related malignancies of plasma cells, it has
been possible to generate a model system of myeloma progression from a normal plasma …
been possible to generate a model system of myeloma progression from a normal plasma …
Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients
Robust establishment of survival in multiple myeloma (MM) and its relationship to recurrent
genetic aberrations is required as outcomes are variable despite apparent similar staging …
genetic aberrations is required as outcomes are variable despite apparent similar staging …
A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial
KD Boyd, FM Ross, L Chiecchio, GP Dagrada, ZJ Konn… - Leukemia, 2012 - nature.com
The association of genetic lesions detected by fluorescence in situ hybridization (FISH) with
survival was analyzed in 1069 patients with newly presenting myeloma treated in the …
survival was analyzed in 1069 patients with newly presenting myeloma treated in the …
A gene expression signature for high-risk multiple myeloma
R Kuiper, A Broyl, Y de Knegt, MH Van Vliet… - Leukemia, 2012 - nature.com
There is a strong need to better predict the survival of patients with newly diagnosed multiple
myeloma (MM). As gene expression profiles (GEPs) reflect the biology of MM in individual …
myeloma (MM). As gene expression profiles (GEPs) reflect the biology of MM in individual …
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t (4; 14) and t (11; 14) myeloma
We have used whole exome sequencing to compare a group of presentation t (4; 14) with t
(11; 14) cases of myeloma to define the mutational landscape. Each case was characterized …
(11; 14) cases of myeloma to define the mutational landscape. Each case was characterized …
Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma
We used genome-wide methylation microarrays to analyze differences in CpG methylation
patterns in cells relevant to the pathogenesis of myeloma plasma cells (B cells, normal …
patterns in cells relevant to the pathogenesis of myeloma plasma cells (B cells, normal …
Map** of Chromosome 1p Deletions in Myeloma Identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as Being Genes in Regions Associated with Adverse Survival
Purpose: Regions on 1p with recurrent deletions in presenting myeloma patients were
examined with the purpose of defining the deletions and assessing their survival impact …
examined with the purpose of defining the deletions and assessing their survival impact …
Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
Outcome in multiple myeloma is highly variable and a better understanding of the factors
that influence disease biology is essential to understand and predict behavior in individual …
that influence disease biology is essential to understand and predict behavior in individual …