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Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …
Despite significant advances in recanalization strategies, patients are still at risk for …
Pathogenic mechanisms following ischemic stroke
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke
Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …
damage. Their morphology and functional changes are correlated with the release of danger …
Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells
CH Huang, TT Yang, KI Lin - Journal of Biomedical Science, 2024 - Springer
SUMOylation, which is a type of post-translational modification that involves covalent
conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates …
conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates …
Ligustrazine nanoparticle hitchhiking on neutrophils for enhanced therapy of cerebral ischemia‐reperfusion injury
Ischemic stroke is a refractory disease that endangers human health and safety owing to
cerebral ischemia. Brain ischemia induces a series of inflammatory reactions. Neutrophils …
cerebral ischemia. Brain ischemia induces a series of inflammatory reactions. Neutrophils …
Innate immunity in the central nervous system
Immune responses in the CNS are common, despite its perception as a site of immune
privilege. These responses can be mediated by resident microglia and astrocytes, which are …
privilege. These responses can be mediated by resident microglia and astrocytes, which are …
[HTML][HTML] Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
V Chhor, T Le Charpentier, S Lebon, MV Oré… - Brain, behavior, and …, 2013 - Elsevier
Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair,
regeneration, and immunosuppression due to their ability to acquire diverse activation …
regeneration, and immunosuppression due to their ability to acquire diverse activation …
Microglia: housekeeper of the central nervous system
Microglia, of myeloid origin, play fundamental roles in the control of immune responses and
the maintenance of central nervous system homeostasis. These cells, just like peripheral …
the maintenance of central nervous system homeostasis. These cells, just like peripheral …
[HTML][HTML] Role of microglia in neurotrauma
Microglia are the primary mediators of the immune defense system of the CNS and are
integral to the subsequent inflammatory response. The role of microglia in the injured CNS is …
integral to the subsequent inflammatory response. The role of microglia in the injured CNS is …
Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders
Recent neuroscience research has established the adult brain as a dynamic organ having a
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …