Advances in artificial intelligence in drug delivery and development: A comprehensive review

AD Gholap, MJ Uddin, M Faiyazuddin, A Omri… - Computers in Biology …, 2024 - Elsevier
Artificial intelligence (AI) has emerged as a powerful tool to revolutionize the healthcare
sector, including drug delivery and development. This review explores the current and future …

[HTML][HTML] Artificial intelligence in pharmaceutical sciences

M Lu, J Yin, Q Zhu, G Lin, M Mou, F Liu, Z Pan, N You… - Engineering, 2023 - Elsevier
Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

TTD: Therapeutic Target Database describing target druggability information

Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for develo** first-in-class drug. A variety …

TheMarker: a comprehensive database of therapeutic biomarkers

Y Zhang, Y Zhou, Y Zhou, X Yu, X Shen… - Nucleic Acids …, 2024 - academic.oup.com
Distinct from the traditional diagnostic/prognostic biomarker (adopted as the indicator of
disease state/process), the therapeutic biomarker (ThMAR) has emerged to be very crucial …

ADCdb: the database of antibody–drug conjugates

L Shen, X Sun, Z Chen, Y Guo, Z Shen… - Nucleic Acids …, 2024 - academic.oup.com
Antibody-drug conjugates (ADCs) are a class of innovative biopharmaceutical drugs, which,
via their antibody (mAb) component, deliver and release their potent warhead (aka. payload) …

VARIDT 3.0: the phenotypic and regulatory variability of drug transporter

J Yin, Z Chen, N You, F Li, H Zhang, J Xue… - Nucleic acids …, 2024 - academic.oup.com
The phenotypic and regulatory variability of drug transporter (DT) are vital for the
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …

INTEDE 2.0: the metabolic roadmap of drugs

Y Zhang, X Liu, F Li, J Yin, H Yang, X Li… - Nucleic acids …, 2024 - academic.oup.com
The metabolic roadmap of drugs (MRD) is a comprehensive atlas for understanding the
stepwise and sequential metabolism of certain drug in living organisms. It plays a vital role in …

SingPro: a knowledge base providing single-cell proteomic data

X Lian, Y Zhang, Y Zhou, X Sun, S Huang… - Nucleic Acids …, 2024 - academic.oup.com
Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …

Application of artificial intelligence in drug design: A review

S Singh, N Kaur, A Gehlot - Computers in Biology and Medicine, 2024 - Elsevier
Artificial intelligence (AI) is a field of computer science that involves acquiring information,
develo** rule bases, and mimicking human behaviour. The fundamental concept behind …

GK BertDTA: a graph representation learning and semantic embedding-based framework for drug-target affinity prediction

X Qiu, H Wang, X Tan, Z Fang - Computers in Biology and Medicine, 2024 - Elsevier
Develo** new drugs is costly, time-consuming, and risky. Drug-target affinity (DTA),
indicating the binding capability between drugs and target proteins, is a crucial indicator for …