NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This
narrative Review provides an overview of the current literature to support the notion that …

Background: Mutations in desmoplakin (DSP), the primary force transducer between cardiac
desmosomes and intermediate filaments, cause an arrhythmogenic form of cardiomyopathy …

Nuclear factor κ-B (NFκB) is activated in iPSC-cardiac myocytes from patients with
arrhythmogenic cardiomyopathy (ACM) under basal conditions, and inhibition of NFκB …

Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic
dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of …

Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac
disease associated with ventricular arrhythmias and an increased risk of sudden cardiac …

Arrhythmogenic cardiomyopathy (ACM) is a primary disease of the myocardium,
predominantly caused by genetic defects in proteins of the cardiac intercalated disc …

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with
ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently …