Glutathione during embryonic development
JM Hansen, C Harris - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background Glutathione (GSH) is a ubiquitous, non-protein biothiol in cells. It plays a variety
of roles in detoxification, redox regulation and cellular signaling. Many processes that can …
of roles in detoxification, redox regulation and cellular signaling. Many processes that can …
The redox theory of development
Significance: The geological record shows that as atmospheric O2 levels increased, it
concomitantly coincided with the evolution of metazoans. More complex, higher organisms …
concomitantly coincided with the evolution of metazoans. More complex, higher organisms …
[HTML][HTML] The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the develo** zebrafish embryo
Redox signaling is important for embryogenesis, guiding pathways that govern processes
crucial for embryo patterning, including cell polarization, proliferation, and apoptosis …
crucial for embryo patterning, including cell polarization, proliferation, and apoptosis …
Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems
Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of …
Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio
The glutathione redox system undergoes precise and dynamic changes during embryonic
development, protecting against and mitigating oxidative insults. The antioxidant response is …
development, protecting against and mitigating oxidative insults. The antioxidant response is …
Real-time analysis of dynamic compartmentalized GSH redox shifts and H2O2 availability in undifferentiated and differentiated cells
BM Davies, JK Katayama, JE Monsivais… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Glutathione (GSH) is the most abundant, small biothiol antioxidant. GSH redox
state (E h) supports developmental processes, yet with disrupted GSH E h, poor …
state (E h) supports developmental processes, yet with disrupted GSH E h, poor …
[HTML][HTML] Map** glutathione utilization in the develo** zebrafish (Danio rerio) embryo
Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles
in organogenesis and embryonic development, however, organ-specific GSH utilization …
in organogenesis and embryonic development, however, organ-specific GSH utilization …
Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression
Abstract Mono-2-ethylhexl phthalate (MEHP) is the primary metabolite of di-2-ethylhexyl
phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how …
phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how …
Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1, 2-dithiole-3-thione …
Redox regulation during metazoan development ensures that coordinated metabolic
reprogramming and developmental signaling are orchestrated with high fidelity in the …
reprogramming and developmental signaling are orchestrated with high fidelity in the …
The chicken embryo as a model in developmental toxicology
MR Stark, MM Ross - Developmental Toxicology: Methods and Protocols, 2019 - Springer
The chicken embryo is a versatile and effective model for studying the effects of teratogenic
compounds during early development. Easy access to the embryo allows for exposure and …
compounds during early development. Easy access to the embryo allows for exposure and …